منابع مشابه
Improved sensitivity of a thyrotropin receptor antibody assay.
Assay, Esther Jensen, Per Hyltoft Petersen, Ole Blaabjerg, Pia Skov Hansen, and Laszlo Hegedüs (Departments of 1 Clinical Biochemistry and 3 Endocrinology and Metabolism, Odense University Hospital, Odense, Denmark; 2 NOKLUS, Norwegian Quality Improvement of Primary Care Laboratories, Division for General Practice, University of Bergen, Bergen, Norway; * address correspondence to this author at...
متن کاملCharacterization of thyrotropin receptor antibody-induced signaling cascades.
The TSH receptor (TSHR) is constitutively active and is further enhanced by TSH ligand binding or by stimulating TSHR antibodies (TSHR-Abs) as seen in Graves' disease. TSH is known to activate the thyroid epithelial cell via both Galphas-cAMP/protein kinase A/ERK and Galphaq-Akt/protein kinase C coupled signaling networks. The recent development of monoclonal antibodies to the TSHR has enabled ...
متن کاملHow sensitive are immunometric assays for thyrotropin?
The usual method for calculation of the "sensitivity" of thyrotropin immunometric assays is multireplicate analysis of the zero analyte standard. Although this is a statistically valid estimate of the scatter likely to be found in the response variable, it is unrelated to normal analytical practice (usually analysis in duplicate) and estimates intra-assay errors only. This study was designed to...
متن کاملNegative correlation between the conversion of thyrotropin receptor-bound blocking type thyrotropin receptor antibody to the stimulating type by anti-human IgG antibodies and the biological activity of blocking type thyrotropin receptor antibody.
It has been reported that receptor-bound blocking type TSH receptor antibody (TRAb) can be converted to the stimulating type by anti-human IgG antibodies. To evaluate the relationship between the conversion of receptor-bound blocking type TRAb to the stimulating type and the biological activity of blocking type TRAb, we compared converting activities of blocking type TRAb from 10 patients with ...
متن کاملThe Role of Thyrotrophin Receptor Antibody Assays in Graves' Disease
Thyrotrophin receptor antibodies (TRAb) exist as stimulating or blocking antibodies in the serum (neutral TRAb have been identified recently). The clinical features of GD occur when stimulating TRAb predominate. But the relationship of TRAb to clinical phenotype and outcome is not clear when current assay methods are used. Therefore no consensus exists about its utility in diagnosing and predic...
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ژورنال
عنوان ژورنال: American Journal of Clinical Pathology
سال: 2013
ISSN: 1943-7722,0002-9173
DOI: 10.1309/ajcpx5vnauyn8mub